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Trends Biotechnol. 2004 Sep;22(9):446-50.

Bow ties, metabolism and disease.

Author information

  • 1Emory Anesthiology Research Labs, 1462 Clifton Rd NE, Room 420, Atlanta GA 30322, USA. doyle@caltech.edu

Abstract

Highly organized, universal structures underlying biological and technological networks mediate effective trade-offs among efficiency, robustness and evolvability, with predictable fragilities that can be used to understand disease pathogenesis. The aims of this article are to describe the features of one common organizational architecture in biology, the bow tie. Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes

PMID:
15331224
DOI:
10.1016/j.tibtech.2004.07.007
[PubMed - indexed for MEDLINE]
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