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Org Lett. 2004 Aug 19;6(17):2873-6.

A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates.

Author information

1
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.

Abstract

Beta-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize beta-2-deoxy sugar phosphates that starts from alpha-glycosyl chlorides. Our approach reliably provides access to a range of NDP beta-2-deoxy sugars essential for studying glycosyltransferases involved in the synthesis of biologically active natural products.

PMID:
15330636
DOI:
10.1021/ol049187f
[Indexed for MEDLINE]

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