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Nucleic Acids Res. 2004 Aug 25;32(15):e121.

Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments.

Author information

1
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the fragments generated by cleavage with these enzymes. Here, we show that the RECORD libraries may be used for digital karyotyping and for pathogen identification by computational subtraction.

PMID:
15329383
PMCID:
PMC516078
DOI:
10.1093/nar/gnh120
[Indexed for MEDLINE]
Free PMC Article

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