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J Int Neuropsychol Soc. 2004 Jul;10(4):639-43.

Hippocampal volume and retention in Alzheimer's disease.

Author information

1
Department of Neurology, University of California at San Francisco, 94143, USA. kramer@itsa.ucsf.edu

Abstract

This study tested the hypothesis that the hippocampus has a relatively specific role in retaining information over delays. Thirty-seven subjects with probable Alzheimer's disease were evaluated with a verbal memory task and structural MRI. Cortical gray matter but not hippocampal volume predicted immediate free recall. In contrast, hippocampal volume was the best predictor of how well information was retained over a delay, even after controlling for levels of immediate recall. Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories.

PMID:
15327742
PMCID:
PMC1820856
DOI:
10.1017/S1355617704104050
[Indexed for MEDLINE]
Free PMC Article

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