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Br J Clin Pharmacol. 2004 Sep;58(3):329-31.

Severe overdosage with the antiepileptic drug oxcarbazepine.

Author information

1
Intensive Care Unit, Maaslandziekenhuis, Sittard, The Netherlands. j.vanopstal@orbisconcern.nl

Abstract

Few published human data are available concerning the acute toxicity of the new antiepileptic drug oxcarbazepine of which the metabolite 10- monohydroxy derivate (MHD) is the pharmacologically effective compound. Two hours after a documented overdosage of more than 100 tablets oxcarbazepine, the serum level of the parent compound was 10-fold higher than the therapeutic dosage (31.6 mg l(-1)). However, the concentration of MHD, which peaked 7 h after intake, was only twofold higher (59.0 mg l(-1)). No life-threatening situations occurred and the patient fully recovered. The fact that oxcarbazepine is a prodrug and that the formation of the active MHD metabolite is a rate-limiting process may contribute to the relative low toxicity of the drug in overdose.

Comment in

PMID:
15327594
PMCID:
PMC1884557
DOI:
10.1111/j.1365-2125.2004.02129.x
[Indexed for MEDLINE]
Free PMC Article

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