Format

Send to

Choose Destination
See comment in PubMed Commons below
Can J Ophthalmol. 2004 Jun;39(4):441-7.

Experimental models of uveal melanoma.

Author information

  • 1Henry C. Witelson Ophthalmic Pathology Laboratory and Registry, McGill University, Montreal, Que. paublanco@hotmail.com

Abstract

Over the past several decades, considerable effort has been directed toward developing suitable experimental models for the study of uveal melanoma. Animal models of uveal melanoma have undergone many improvements, leading to the development of experimental systems that better represent the disease in human beings. A major advance has come from the use of human uveal melanoma cell lines capable of inducing tumour growth and metastatic disease in immunodeficient hosts. Knowledge gained from the use of experimental models will ultimately be translated into better diagnostic and therapeutic strategies for patients with uveal melanoma. In this review the authors describe the current state-of-the-art designs of experimental models of uveal melanoma, highlighting the advantages and disadvantages of the available models. Novel findings from a rabbit model of uveal melanoma are also presented.

PMID:
15327111
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center