Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13268-72. Epub 2004 Aug 23.

Comparative immunopeptidomics of humans and their pathogens.

Author information

1
Celera Genomics, Rockville, MD 20850, USA. sorin.istrail@appliedbiosystems.com

Abstract

Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH(2)-terminal leader sequences.

PMID:
15326311
PMCID:
PMC516558
DOI:
10.1073/pnas.0404740101
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center