Format

Send to

Choose Destination
Clin Perinatol. 2004 Sep;31(3):453-73.

Prematurity and intrauterine growth retardation--double jeopardy?

Author information

1
Neonatal Unit and Neonatal Follow-Up Clinic, Neonatal Department, Meir Hospital, Sapir Medical Center, Kfar Saba 44281, Israel. regevdr@netvision.net.il

Abstract

Premature infants born with IUGR are at a several-fold increased risk for mortality and major neonatal morbidities, including RDS, BPD, ROP, and NEC. These severe complications of prematurity are intensified by the effect of suboptimal fetal growth. The possible pathophysiologic processes initiated in utero and continuing after birth have been discussed. Recently reported data suggest that IUGR is a risk factor in programming for the later development of cardiovascular diseases, hypertension, and diabetes mellitus in adult life. Experimental research related to the pathophysiology and etiology of these conditions may enable appropriate intervention directed at reducing the excess risk associated with the short- and long-term mortality and morbidity among premature SGA infants.

PMID:
15325532
DOI:
10.1016/j.clp.2004.04.017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center