Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Nephrol. 2004 Nov;19(11):1189-91. Epub 2004 Aug 20.

NF-kappaB as a molecular link between psychosocial stress and organ dysfunction.

Abstract

It is well accepted that psychosocial stress contributes to the pathogenesis of hypertension, cardiovascular disease, and renal disease. Although even lay persons are aware that stress can be dangerous to health, the molecular mechanisms by which psychosocial events contribute to cellular dysfunction have hitherto been poorly understood by scientists. The pro-inflammatory transcription factor NF-kappaB has recently been identified as a potential critical bridge between stress and cellular activation. NF-kappaB activation, in turn, is known to play a pivotal role in vascular and renal disease. Activation of NF-kappaB, evoked by psychosocial stress, may directly target vessels and kidneys and thus represent an additional risk factor for cardiovascular and renal disease.

PMID:
15322889
DOI:
10.1007/s00467-004-1603-0
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center