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Infect Immun. 2004 Sep;72(9):5526-9.

Parameters of the attenuated schistosome vaccine evaluated in the olive baboon.

Author information

1
Institute of Primate Research, Karen, Nairobi, Kenya.

Abstract

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

PMID:
15322059
PMCID:
PMC517471
DOI:
10.1128/IAI.72.9.5526-5529.2004
[Indexed for MEDLINE]
Free PMC Article

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