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Am J Clin Nutr. 2004 Sep;80(3):621-5.

Moderate wine drinkers have lower hypertension-related mortality: a prospective cohort study in French men.

Author information

1
Hospital Emile Roux, Pavillon Buisson Jacob, 94456 Limeil-Brévannes, France. serge.renaud@erx.ap-hop-paris

Abstract

BACKGROUND:

For a given blood pressure, the risk of death from coronary artery disease is much higher in northern Europe and the United States than in Mediterranean countries.

OBJECTIVE:

In this prospective cohort study, we tested the hypothesis that regular wine drinking reduces the hypertension-related risk of death.

DESIGN:

We used data from 36 583 healthy middle-aged men who had normal results on an electrocardiogram and were not taking drugs for cardiovascular disease risk factors. The subjects underwent a comprehensive health appraisal at the Center for Preventive Medicine between 1 January 1978 and 31 December 1985. Mortality from all causes and from specific causes during a 13-21-y follow-up was recorded.

RESULTS:

In a Cox model adjusted for 6 confounding variables, moderate wine drinkers (those who consumed <60 g alcohol/d and no beer) with systolic blood pressure (SBP) of 158, 139, or 116 mm Hg had significantly lower risks of death from all causes by 23%, 27%, and 37%, respectively, than did abstainers. Even for the highest quartile of blood pressure, moderate wine drinkers were protected from all-cause mortality. No significant reduction in all-cause mortality in relation to SBP was observed in other drinkers (those who consumed > or =60 g alcohol/d or who consumed beer and wine).

CONCLUSION:

A moderate intake of wine is associated with a lower risk of mortality from all causes in persons with hypertension.

PMID:
15321801
DOI:
10.1093/ajcn/80.3.621
[Indexed for MEDLINE]

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