Format

Send to

Choose Destination
See comment in PubMed Commons below
J Allergy Clin Immunol. 2004 Aug;114(2):265-9.

Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma.

Author information

1
Division of Respiratory and Critical Care Medicine, University of Missouri-Kansas City School of Medicine, MO 64108-2792, USA. obay@umkc.edu

Abstract

BACKGROUND:

Omalizumab can reduce hospitalization and emergency department visits and improve quality of life in patients with moderate-to-severe, suboptimally controlled allergic asthma. Given the high cost and modest efficacy of this agent, it is not clear that it is cost-effective if given to a broad population with asthma.

OBJECTIVE:

The purpose of this study was to evaluate the cost-effectiveness of omalizumab in adults and adolescents with moderate-to-severe allergic asthma.

METHODS:

A retrospective economic analysis was performed to determine the cost-effectiveness of omalizumab using 52-week data from 2 randomized controlled clinical trials in adults and adolescents with moderate-to-severe allergic asthma. The analysis was conducted from a third-party payer's perspective, and only direct costs were considered.

RESULTS:

The incremental cost-effectiveness ratios showed that the cost to achieve an additional successfully controlled day was $523, and the daily cost to achieve at least a 0.5-point increase in Asthma Quality of Life Questionnaire score was $378 in 2003 dollars.

CONCLUSION:

From a pharmacoeconomic standpoint, omalizumab would be better used in allergic asthmatic patients with poorly controlled symptoms despite maximal therapy, given the high cost and modest efficacy of this agent. It could be cost saving if given to nonsmoking patients who are hospitalized 5 or more times or 20 days or longer per year despite maximal asthma therapy.

PMID:
15316501
DOI:
10.1016/j.jaci.2004.05.049
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center