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Int Arch Allergy Immunol. 2004 Sep;135(1):40-3. Epub 2004 Aug 13.

Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis.

Author information

1
Department of Environmental Medicine, Kochi University School of Medicine, Kohasu, Okoh-cho, Nankoku 783-8505, Japan. hiro-n@po.incl.ne.jp

Abstract

BACKGROUND:

Japanese cedar pollinosis is the most common form of hay fever in spring in Japan. We have previously demonstrated that single nucleotide polymorphism Pro358Leu of exon 7 in the eosinophil peroxidase (EPO) gene is associated with cedar pollinosis, although the association has not been confirmed by analysis of the whole gene in a different population.

METHODS:

We sequenced all exons of the EPO gene in 60 children with pollinosis and their parents using the PCR-restriction fragment length polymorphism method.

RESULTS:

We found 8 polymorphisms, Ile40Met, Gln122His, Arg202Arg (A660G), Asn303Asn (C909T), Arg326Pro, Arg326His, Pro358Leu, and Asn572Ty, in the EPO gene. As a result of the transmission disequilibrium test, we recognized significant transmissions of 202Arg (660G) in exon 6 in addition to 358Leu of exon 7 in the EPO gene of affected children.

CONCLUSIONS:

Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis.

PMID:
15316147
DOI:
10.1159/000080222
[Indexed for MEDLINE]
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