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Vaccine. 2004 Sep 9;22(27-28):3691-7.

Protollin: a novel adjuvant for intranasal vaccines.

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ID Biomedical Corporation of Quebec, 7150 Frederick Banting, Ville St-Laurent, Montreal, QC, Canada H4S 2A1.


Protollin is a novel adjuvant comprising Proteosomes non-covalently complexed with LPS. Intranasal immunization of mice with Protollin combined with detergent-split influenza antigens (HA) or recombinant influenza hemagglutinin (rHA) enhanced serum IgG and mucosal IgA levels by up to 250-fold compared with immunization with the antigens alone. IFN-gamma responses were also enhanced compared to the levels produced by splenocytes from mice immunized with antigen alone, while production of IL-5 was abrogated. Mice immunized with Protollin-rHA were completely protected against lethal challenge with influenza virus, demonstrating that Protollin is an effective mucosal adjuvant for prophylactic vaccines.

[Indexed for MEDLINE]

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