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Cell. 2004 Aug 20;118(4):431-8.

AID is required for c-myc/IgH chromosome translocations in vivo.

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1
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA.

Abstract

Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.

PMID:
15315756
DOI:
10.1016/j.cell.2004.08.006
[Indexed for MEDLINE]
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