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J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1346-8.

Intraventricular cytarabine in a case of idiopathic hypertrophic pachymeningitis.

Author information

  • 1University of Regensburg, Department of Neurology, Universit├Ątsstrasse 84, 93042 Regensburg, Germany. ingo.kleiter@klinik.uni-regensburg.de

Abstract

Idiopathic hypertrophic chronic pachymeningitis (IHCP) is characterised by inflammatory fibrotic thickening of the dura mater. Long term management is controversial. A 28 year old man with craniospinal IHCP and prominent lymphocytic meningitis is reported. Cerebrospinal fluid and histological examination suggested a CD4+ T cell driven process and B cell stimulation. After surgical, tuberculostatic, and immunosuppressive treatment failed to control the progressive meningeal hypertrophy, causing severe headache and neurological disability, the disease process eventually abated with intraventricular cytarabine treatment.

PMID:
15314132
PMCID:
PMC1739231
DOI:
10.1136/jnnp.2003.024653
[PubMed - indexed for MEDLINE]
Free PMC Article
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