Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Dermatol. 2004 Aug;140(8):963-9.

Adverse effects of systemic glucocorticosteroid therapy in infants with hemangiomas.

Author information

1
Section of Dermatology, Children's Mercy Hospital, Kansas City, MO, USA. mgeorge@kumc.edu

Abstract

OBJECTIVE:

To evaluate the short- and long-term adverse effects of systemic glucocorticosteroid (GS) therapy in infants with hemangiomas.

DESIGN:

Retrospective chart review of infants treated with GSs for hemangiomas during a 3-year period.

SETTING:

Tertiary care children's hospital.

PATIENTS:

Of 141 patients identified with hemangiomas, 22 were treated with GSs.

INTERVENTIONS:

Minimum of 1-month GS therapy at a minimum starting dose of 0.5 mg/kg per day.

OUTCOME MEASURES:

Demographic and anthropometric measurements, starting dose and duration of GS therapy, subjective parental concerns, complications related to hemangioma, adjunctive treatment, and morning cortisol levels and/or results of corticotropin stimulation tests.

RESULTS:

The average starting dose was 2.23 mg/kg per day; average length of therapy was 28.1 weeks. Complaints of irritability, fussiness, or insomnia were identified in 16 patients (73%). Hypertension, defined as 3 or more episodes of systolic blood pressure higher than 105 mm Hg, was observed in 10 patients (45%). Morning cortisol levels were abnormal in 13 (87%) of the 15 patients evaluated. Low-dose corticotropin stimulation test results were abnormal in 2 of the 3 infants tested.

CONCLUSIONS:

While GS therapy for infantile hemangiomas was tolerated well overall, changes in behavior, insomnia, and gastrointestinal symptoms were common parental concerns. Hypertension and hypothalamic-pituitary-adrenal axis suppression were observed frequently. Infants undergoing long-term GS treatment of hemangiomas should be monitored carefully for these potential adverse effects.

PMID:
15313812
DOI:
10.1001/archderm.140.8.963
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center