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J Am Coll Nutr. 2004 Aug;23(4):351-7.

Effects of acute chromium supplementation on postprandial metabolism in healthy young men.

Author information

1
INW Nutrition Biology, Department of Agriculture and Food Sciences, Swiss Federal Institute of Technology Zurich, Switzerland.

Abstract

BACKGROUND:

Chromium (Cr) potentiates the action of insulin in the cell and improves glucose tolerance after long-term supplementation.

OBJECTIVE:

We hypothesized that Cr may also have acute effects and might be beneficial in lowering the glycemic index of a meal.

METHODS:

We studied the effects of short-term Cr supplementation using a randomized crossover design. Thirteen apparently healthy, non-smoking young men of normal body mass index performed three trials each separated by one week. Test meals, providing 75 g of available carbohydrates, consisted of white bread with added Cr (400 or 800 microg as Cr picolinate) or placebo.

RESULTS:

After addition of 400 and 800 microg Cr incremental area under the curve (AUC) for capillary glucose was 23% (p = 0.053) and 20% (p = 0.054), respectively, lower than after the white bread meal. These differences reached significance if the subjects were divided into responders (n = 10) and non-responders (n = 3). For the responders AUC after 400 and 800 microg Cr was reduced by 36% and 30%, respectively (Placebo 175 +/- 22, Cr400 111 +/- 14 (p < 0.01), Cr800 122 +/- 15 mmol. min/L (p < 0.01)). Glycemia was unchanged after addition of Cr in the non-responders. Responders and non-responders differed significantly in their nutrient intake and eating pattern, and total serum iron concentration tended to be lower in the responder group (p = 0.07).

CONCLUSIONS:

Acute chromium supplementation showed an effect on postprandial glucose metabolism in most but not all subjects. The response to Cr may be influenced by dietary patterns.

PMID:
15310739
[Indexed for MEDLINE]

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