Format

Send to

Choose Destination
Trends Mol Med. 2004 Aug;10(8):372-8.

Mitochondria as cancer drug targets.

Author information

1
Centre for Vascular Research, University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney NSW 2052, Australia.

Abstract

Cancer cells are defined by their unlimited replicative potential and resistance to cell death stimuli. It is generally considered that a point of no return in apoptotic cell death is the permeabilisation of the mitochondrial membranes. For this reason, agents that permeabilise cancer cell mitochondria have the potential to circumvent their resistance to apoptotic cell death. Fortunately, the proliferative and bioenergetic differences between normal and cancerous cells provide an opportunity to selectively target cancer cell mitochondria.

PMID:
15310457
DOI:
10.1016/j.molmed.2004.06.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center