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Med Clin North Am. 2004 Jul;88(4):947-99, xi.

Diabetic neuropathies.

Author information

1
Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA. vinikai@evms.edu

Abstract

Diabetic neuropathy (DN) is a common complication of diabetes that often is associated with considerable morbidity and mortality. The epidemiology and natural history of DN is clouded with uncertainty because of confusion regarding the definition and measurement of this disorder. The recent resurgence of interest in the vascular hypothesis, oxidative stress, the neurotrophic hypothesis,and the possibility of the role of autoimmunity has opened up new avenues of investigation for therapeutic intervention. The ability to manage successfully the many different manifestations of diabetic neuropathy depends ultimately on success in uncovering the pathogenic processes underlying this disorder.

PMID:
15308387
DOI:
10.1016/j.mcna.2004.04.009
[Indexed for MEDLINE]

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