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Neurosci Lett. 2004 Aug 26;367(1):109-12.

Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity.

Author information

1
Division of Research, SingHealth, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. gnrtek@sgh.com.sg

Abstract

Mutations in the DJ-1 gene have been described in autosomal recessive Parkinson's disease patients (ARPD) of European ancestry and young onset (YOPD) Ashkenazi Jewish and Afro-Caribbean patients. There is little information on the prevalence of DJ-1 mutations amongst Asian PD populations. In this study, we examined for DJ-1 mutations in consecutive YOPD and ARPD in a multi-ethnic cohort (Chinese, Malays, and Indians) of PD patients in a tertiary referral center. Sequence analysis of all the exons and the exon and intron boundaries of the DJ-1 gene were carried out. We did not find any DJ-1 mutations in these patients. A number of intronic variants with genotype frequency ranging from 15 to 90% were detected. Unlike Parkin, pathogenic DJ-1 mutations appear to be restricted to certain populations and are unlikely to be of clinical importance in our Asian cohort.

PMID:
15308309
DOI:
10.1016/j.neulet.2004.05.090
[Indexed for MEDLINE]

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