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Trends Cell Biol. 2004 Aug;14(8):408-12.

The interaction between FOXO and SIRT1: tipping the balance towards survival.

Author information

1
Department of Biology, University College London, London WC1E 6BT, UK.

Abstract

When overexpressed, the NAD-dependent protein deacetylase Sir2 extends the lifespan of both budding yeast and the nematode worm Caenorhabditis elegans. In the worm, this extension of lifespan requires the FOXO transcription factor daf-16. Three recent articles focusing on mammalian homologues of Sir2 and FOXO have highlighted the mechanisms that generate this genetic interaction. Mammalian SIRT1 deacetylates FOXO3 and/or FOXO4, thus attenuating FOXO-induced apoptosis and potentiating FOXO-induced cell-cycle arrest. SIRT1 might increase longevity by shifting FOXO dependent responses away from cell death and towards cell survival.

PMID:
15308206
DOI:
10.1016/j.tcb.2004.07.006
[Indexed for MEDLINE]

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