Format

Send to

Choose Destination
Immunity. 2004 Aug;21(2):149-53.

Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models.

Author information

1
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. jyewdell@nih.gov

Abstract

Highlights from a FundaciĆ³n Juan March Interdisciplinary Meeting. CD8+ T cells (TCD8+) play a critical role in immunity to viruses. A central feature of antiviral TCD8+ responses is immunodominance: out of thousands of potential target peptides, only a handful generate measurable responses. A recent FundaciĆ³n Juan March Meeting brought together scientists working on the various steps in antigen presentation and T cell biology that contribute to immunodominance, whose understanding is key to rationally developing vaccines meant to elicit effective antiviral TCD8+ responses.

PMID:
15308096
DOI:
10.1016/j.immuni.2004.06.015
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center