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Immunity. 2004 Aug;21(2):149-53.

Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models.

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Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.


Highlights from a FundaciĆ³n Juan March Interdisciplinary Meeting. CD8+ T cells (TCD8+) play a critical role in immunity to viruses. A central feature of antiviral TCD8+ responses is immunodominance: out of thousands of potential target peptides, only a handful generate measurable responses. A recent FundaciĆ³n Juan March Meeting brought together scientists working on the various steps in antigen presentation and T cell biology that contribute to immunodominance, whose understanding is key to rationally developing vaccines meant to elicit effective antiviral TCD8+ responses.

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