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Dev Dyn. 2004 Sep;231(1):199-203.

Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin.

Author information

1
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Abstract

We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin. Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair-cell-specific gene targeting.

PMID:
15305300
DOI:
10.1002/dvdy.20106
[Indexed for MEDLINE]
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