Send to

Choose Destination
FEBS Lett. 2004 Aug 13;572(1-3):147-53.

Close head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster.

Author information

Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA 92182-4614, USA.


This report identifies a large number of gene-pairs in Drosophila melanogaster that share a common upstream region. 877 gene-pairs (approximately 12% of the genome) are separated by less than 350 bp in a head-to-head orientation. This positional relationship is more highly favored in flies than in other organisms. These gene pairs have a higher correlation of expression than similarly spaced genes that have head-to-tail or tail-to-tail orientations. Thus, the positional arrangement of genes appears to play a significant role in coordinating relative expression patterns and may provide clues for identifying the functions of unknown genes.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center