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J Am Chem Soc. 2004 Aug 18;126(32):9918-9.

Highly efficient synthesis of beta-amino acid derivatives via asymmetric hydrogenation of unprotected enamines.

Author information

1
Department of Process Research, Merck Research Laboratories, Merck and Co., Inc., Rahway, New Jersey 07065, USA. yi_xiao@merck.com

Abstract

A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives beta-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required.

PMID:
15303855
DOI:
10.1021/ja047901i
[Indexed for MEDLINE]
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