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Acta Paediatr. 2004 Jul;93(7):999-1001.

Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants.

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Division of Neonatology, Department of Paediatrics, Dokuz Eylul University, Izmir, Turkey.



To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment.


Clinical and laboratory records of two preterm infants, who developed intestinal perforation after ibuprofen administration, were evaluated.


Gestational ages of infants were 29 wk (male) and 30 wk (female). Both infants developed intestinal perforations without signs of necrotizing enterocolitis. The perforations cured with Penrose drainage alone.


Although ibuprofen is a reasonable treatment alternative to indomethacin, randomized controlled trials, which address potential adverse effects including spontaneous intestinal perforation, are needed.

[Indexed for MEDLINE]

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