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Acta Paediatr. 2004 Jul;93(7):999-1001.

Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants.

Author information

1
Division of Neonatology, Department of Paediatrics, Dokuz Eylul University, Izmir, Turkey.

Abstract

AIM:

To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment.

METHODS:

Clinical and laboratory records of two preterm infants, who developed intestinal perforation after ibuprofen administration, were evaluated.

RESULTS:

Gestational ages of infants were 29 wk (male) and 30 wk (female). Both infants developed intestinal perforations without signs of necrotizing enterocolitis. The perforations cured with Penrose drainage alone.

CONCLUSION:

Although ibuprofen is a reasonable treatment alternative to indomethacin, randomized controlled trials, which address potential adverse effects including spontaneous intestinal perforation, are needed.

[Indexed for MEDLINE]

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