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Biochem Biophys Res Commun. 2004 Aug 6;320(4):1306-8.

The 10 C-terminal residues of HTLV-I protease are not necessary for enzymatic activity.

Author information

1
Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta 30332-0400, USA.

Abstract

Sequence alignment of human T-lymphotropic virus type I (HTLV-I) protease and other retroviral proteases reveals that the leukemia virus proteases contain residues at the C-terminus that are absent in the other proteases. We have prepared a mutant of HTLV-I protease that does not contain the 10 C-terminal residues and demonstrated that the catalytic efficiency of cleavage of a peptide substrate is unaffected.

PMID:
15303275
DOI:
10.1016/j.bbrc.2004.06.087
[Indexed for MEDLINE]

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