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Am J Obstet Gynecol. 1992 Sep;167(3):661-6.

Effect of magnesium sulfate on maternal brain blood flow in preeclampsia: a randomized, placebo-controlled study.

Author information

1
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.

Abstract

OBJECTIVES:

The purpose of this study was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal brain blood flow velocity waveforms in patients with preeclampsia.

STUDY DESIGN:

Twelve patients with preeclampsia were randomized to two groups and studied with Doppler ultrasonography before and immediately after infusion of either a 6 gm intravenous loading dose of magnesium sulfate or a placebo. The middle cerebral, common carotid, and internal carotid arteries were studied.

RESULTS:

Magnesium sulfate significantly reduced the pulsatility index in the middle cerebral artery (change in pulsatility index = -0.16 + 0.09) when compared with the placebo (change in pulsatility index = -0.02 + 0.06), p = 0.01. There were no significant changes in the Doppler indexes of the carotid vessels.

CONCLUSIONS:

These data suggest that magnesium sulfate vasodilates the smaller-diameter intracranial vessels distal to the middle cerebral artery and may exert its main effect in the prophylaxis and treatment of eclampsia by relieving cerebral ischemia.

PMID:
1530019
DOI:
10.1016/s0002-9378(11)91567-1
[Indexed for MEDLINE]

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