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Curr Biol. 2004 Aug 10;14(15):R613-4.

Telomeres: not all breaks are equal.

Author information

1
Molecular, Cellular and Developmental Biology, 347UCB, University of Colorado, Boulder, Colorado, USA. amanda.purdy@colorado.edu

Abstract

ATM, Rad50 and Mre11 have been shown to prevent telomere fusion in Drosophila, thereby extending the protective role of DNA damage checkpoint proteins to non-canonical telomeres formed without telomerase. How do these proteins help chromosomal termini escape fusion through 'repair' while promoting repair of induced DNA breaks?

PMID:
15296775
DOI:
10.1016/j.cub.2004.07.042
[Indexed for MEDLINE]
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