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J Infect Dis. 2004 Sep 1;190(5):967-70. Epub 2004 Jul 27.

Effects of glucose on fsr-mediated biofilm formation in Enterococcus faecalis.

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Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.


Biofilm production is frequently dependent on such environmental factors as cell density and glucose concentration. The Enterococcus faecalis quorum-sensing locus (fsr) increases enterococcal virulence in multiple animal models. To date, fsr has been shown to regulate the transcription of 2 downstream protease genes. We demonstrate that the effect of fsr mutations on biofilm formation, as well as the fsr-mediated catabolite control of biofilm, is mediated via these proteases. The present study provides additional insight into the mechanisms used by E. faecalis to establish nosocomial infection.

[Indexed for MEDLINE]

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