Format

Send to

Choose Destination
Eur J Hum Genet. 2004 Nov;12(11):949-54.

Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.

Author information

1
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.

Abstract

Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value = 9.8 x 10(-5)). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL.

PMID:
15292919
DOI:
10.1038/sj.ejhg.5201239
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center