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Oncol Rep. 2004 Sep;12(3):659-62.

Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro.

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Department of Medicine, Center for Human Nutrition, University of California-Los Angeles, Los Angeles, CA 90095, USA.


This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 micro g/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.

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