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Am J Ophthalmol. 2004 Aug;138(2):310-3.

Conjunctival hyperemia associated with bimatoprost use: a histopathologic study.

Author information

1
Department of Ophthalmology, Glaucoma Service, University of São Paulo, São Paulo, Brazil.

Abstract

PURPOSE:

To evaluate histopathologic signs of conjunctival inflammation in patients with conjunctival hyperemia induced by bimatoprost treatment.

DESIGN:

Prospective interventional study.

METHODS:

The study included 15 eyes of 15 patients scheduled for cataract surgery. Patients in the treatment group (n = 9) exhibited trace to moderate conjunctival hyperemia when treated with bimatoprost 0.03% every day for 15 to 30 days before surgery. The control group (n = 6) included untreated patients with no ocular disease other than cataract. Conjunctival biopsies were obtained for histologic evaluation with light microscopy.

RESULTS:

Vascular congestion was observed in biopsies from 7 patients (78%) in the bimatoprost group and 5 patients (83%) in the control group. Signs of inflammation were found in biopsies from 2 patients (22%) in the bimatoprost group and 2 patients (33%) in the control group.

CONCLUSIONS:

Histopathologic signs of inflammation were no more frequent in conjunctival specimens from bimatoprost-treated patients with trace to moderate hyperemia than in those from untreated control subjects.

PMID:
15289152
DOI:
10.1016/j.ajo.2004.03.006
[Indexed for MEDLINE]

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