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Trends Biochem Sci. 2004 Aug;29(8):396-9.

GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding.

Author information

1
Microbial Genomics Group, Institute for Biomedical Research, Division of Immunity and Infection, Medical School, University of Birmingham, Birmingham, UK B15 2TT.

Abstract

We describe GIFT [for GldG, intraflagellar transport (IFT)] domains in the flavobacterial gliding protein GldG and eukaryotic IFT-52. In eukaryotes, domain homologues are also found in the eukaryotic oligosaccharyltransferase complex and in subtilisin kexin isozyme-1 (SKI-1 or S1P). A distant evolutionary relationship to periplasmic-binding proteins hints that GIFT domains might possess oligosaccharide-binding functions.

PMID:
15288869
DOI:
10.1016/j.tibs.2004.06.002
[Indexed for MEDLINE]

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