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Curr Opin Microbiol. 2004 Aug;7(4):369-74.

Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries.

Author information

1
Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium. epays@ulb.ac.be

Abstract

Antigenic variation allows African trypanosomes to develop chronic infections in mammalian hosts. This process results from the alternative occurrence of transcriptional switching and DNA recombination targeted to a telomeric locus that contains the gene of the variant antigen and is subjected to mono-allelic expression control. So far, the identification of mechanisms and factors involved still resists technological developments and genome sequencing.

PMID:
15288623
DOI:
10.1016/j.mib.2004.05.001
[Indexed for MEDLINE]

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