Format

Send to

Choose Destination
J Org Chem. 2004 Aug 6;69(16):5468-70.

A Highly stereospecific and efficient synthesis of homopentafluoro- phenylalanine.

Author information

1
Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA.

Abstract

A short and efficient synthesis of homopentafluorophenylalanine (6) from oxazolidine aldehyde 1 in 57% overall yield and in > 98% ee is described. The enantiomeric excess of the product was determined by 19F NMR analysis of the coupling product derived from 5 and L-Ser(O-t-Bu)-OCH3, by comparison to a dipeptide obtained from racemic 5.

PMID:
15287798
DOI:
10.1021/jo049206z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center