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Am J Psychiatry. 2004 Aug;161(8):1485-7.

Differential response to placebo among patients with social phobia, panic disorder, and obsessive-compulsive disorder.

Author information

1
Center for Treatment and Study of Anxiety, University of Pennsylvania School of Medicine, 6th Floor, 3535 Market St., Philadelphia, PA 19104, USA. huppert@mail.med.upenn.edu

Abstract

OBJECTIVE:

Placebo effects in treatment of three anxiety disorders were compared.

METHOD:

Treatment response and patients' treatment expectancy were examined by using data from 70 patients with obsessive-compulsive disorder, social phobia, or panic disorder who received placebo in three randomized, controlled trials comparing cognitive behavior therapy, medication, and their combination to placebo.

RESULTS:

Patients with obsessive-compulsive disorder were less likely to respond to placebo than patients with generalized social phobia or panic disorder. Differential expectancy did not account for these findings.

CONCLUSIONS:

Further examination of the placebo effect across the anxiety disorders may elucidate maintenance mechanisms of these disorders and have implications for development of more effective treatments.

PMID:
15285978
DOI:
10.1176/appi.ajp.161.8.1485
[Indexed for MEDLINE]

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