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Acta Neurol Scand. 2004 Sep;110(3):161-5.

Internuclear ophthalmoplegia: causes and long-term follow-up in 65 patients.

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1
Department of Neuroophthalmology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, México.

Abstract

OBJECTIVES:

To analyze the causes and long-term clinical outcome of internuclear ophthalmoplegia (INO) in a consecutive series of 65 patients.

PATIENTS AND METHODS:

From a clinical registry of a neuroophthalmological department, patients with diagnosis of INO were retrospectively identified. Patients were classified into three groups: unilateral INO, bilateral INO, and one-and-a-half syndrome.

RESULTS AND CONCLUSIONS:

Thirty-three men (50.8%) and 32 women (49.2%), with a mean age of 38.4 years were included in the study. INO was unilateral in 36 patients (55.4%), bilateral in 22 (33.8%) and one-and-a-half syndrome in seven (10.8%). The most common causes were vascular (36.9%), multiple sclerosis (32.3%), and infectious diseases (13.8%). Resolution of INO was documented in 32 patients (49.2%): 15 patients showed INO resolution during the first 3 months and 17 patients in 3-9 months. INO persisted in 33 patients (50.8%) even after a follow-up longer than 12 months.

[Indexed for MEDLINE]

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