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World J Gastroenterol. 2004 Aug 15;10(16):2327-9.

New serum biomarkers for detection of HBV-induced liver cirrhosis using SELDI protein chip technology.

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  • 1Department of Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Zhongguancun Beiyitiao, Beijing 100080, China.

Abstract

AIM:

To find new serum biomarkers for liver cirrhosis (LC) in chronic carriers of hepatitis B virus (HBV).

METHODS:

Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers for differentiating HBV induced LC from non-cirrhotic cohorts. A training population of 25 patients with HBV-induced LC, 20 patients with HCC, and 25 closely age-matched healthy men, was studied.

RESULTS:

Two biomarkers with M(r) 7 772 and 3 933 were detected in sera of non-cirrhotic cohorts, but not in patients with HBV-induced LC. A sensitivity of 80% for all LC patients, a specificity of 81.8% for all non-cirrhotic cohorts and a positive predictive value of 75% for the study population were obtained.

CONCLUSION:

These two serum biomarkers for HBV-induced LC might be used for diagnosis and assessment of disease progression.

PMID:
15285013
PMCID:
PMC4576282
[PubMed - indexed for MEDLINE]
Free PMC Article
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