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J Trauma. 2004 Jul;57(1 Suppl):S26-8.

Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.

Author information

1
Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA. rconnolly@tufts-nemc.org

Abstract

BACKGROUND:

The Rapid Deployment Hemostat (RDH) Bandage was developed for the rapid control of bleeding caused by trauma.

METHODS:

An extremity wound involving skin, muscle, bone, and femoral arterial injury and a 1-cm vertical incision in the abdominal aorta in swine were studied to compare the RDH Bandage, a fibrin sealant dressing and gauze to restore hemostasis. The total blood loss was determined and the survival of animals was measured.

RESULTS:

In the extremity injury model, the RDH Bandage reduced blood loss by 63% compared with the gauze control. In the aorta arterial incision model, the RDH Bandage required a significantly lower compression time to control bleeding compared with gauze and TachoComb. The RDH Bandage was able to stop bleeding from this injury in 100% of the tests.

CONCLUSION:

The RDH Bandage was superior to a commercially available fibrin bandage in controlling hemorrhage, decreasing blood loss, and increasing survival.

PMID:
15280747
[Indexed for MEDLINE]

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