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Cell Cycle. 2004 Aug;3(8):1002-4. Epub 2004 Aug 25.

Geminin: a major DNA replication safeguard in higher eukaryotes.

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European Institute of Oncology, Department of Experimental Oncology, Milan, Italy.


Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.

[Indexed for MEDLINE]

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