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Genetics. 2004 Jul;167(3):1525-8.

Does random X-inactivation in mammals reflect a random choice between two X chromosomes?

Author information

1
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Inactivation of the maternal or paternal X chromosome in a mammalian embryonic XX cell is believed to involve random choice between the two X's. We propose two alternative models. One suggests that choice is not random, while the other is consistent with random choice, but not one between two X's.

PMID:
15280260
PMCID:
PMC1470940
DOI:
10.1534/genetics.104.029819
[Indexed for MEDLINE]
Free PMC Article

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