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Rev Med Interne. 2004 Aug;25(8):556-61.

[Update of pernicious anemia. A retrospective study of 49 cases].

[Article in French]

Author information

1
Service de médecine interne, diabète et maladies métaboliques de la clinique médicale B, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.

Abstract

PURPOSE:

The aim of this study was to describe the present clinical characteristics of the pernicious anemia (PA).

METHOD:

It is a retrospective (1996-2002) multicenter (five departments of internal medicine) study of 49 patients presenting an established cobalamin deficiency related to PA.

RESULTS:

The median age of the patients was 74 years (25-93), the female/male ratio 2:9. Several autoimmune disorders were noted in 35% of the patients. Various clinical manifestations, mainly neurological, cutaneous and thrombotic, were found in 65.4% of the patients, at least one hematological abnormalities in 100%. Average serum vitamin B12 and homocystein levels were with 73 pg/ml (20-1960) and 42.9 micromol/l (7, 8-124). Anti-intrinsic factor or anti-parietal gastric cells antibodies were found in 87.5% and 62% of the patients (at least one antibody, in 96%) abnormal Schilling's test results in 86%. All the followed patients were successful treated with intramuscular (n = 27) or oral crystalline cyanocobalamin (n = 5).

CONCLUSIONS:

PA was associated with several autoimmune disorders; PA may be responsible of various clinical manifestations or biological abnormalities; and oral crystalline cyanocobalamin treatment may be successful.

PMID:
15276287
DOI:
10.1016/j.revmed.2004.03.008
[Indexed for MEDLINE]

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