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Trends Biochem Sci. 2004 Jun;29(6):285-9.

MT1-MMP: an enzyme with multidimensional regulation.

Author information

1
Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, UK.

Abstract

The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.

PMID:
15276180
DOI:
10.1016/j.tibs.2004.04.001
[Indexed for MEDLINE]

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