Format

Send to

Choose Destination
See comment in PubMed Commons below
Seizure. 2004 Sep;13(6):399-402.

Determination of language dominance with near-infrared spectroscopy: comparison with the intracarotid amobarbital procedure.

Author information

1
Department of Neurology, University of Washington Regional Epilepsy Center, Box 359745, 325 Ninth Avenue, Seattle, WA 98104-2499, USA. nwatson@u.washington.edu

Abstract

PURPOSE:

To determine the efficacy of near-infrared spectroscopy (NIRS) in identifying the hemisphere associated with language by measuring changes in bilateral lateral inferior frontal blood flow during a word generation task in epilepsy surgery patients and healthy volunteers.

METHODS:

Sixteen patients who underwent the intracarotid amobarbital procedure (IAP) and eight healthy right-handed/right-footed individuals were tested with NIRS during a word generation paradigm.

RESULTS:

Increases in lateral inferior frontal total hemoglobin concentrations agreed with the IAP in 11 of 16 patients, including 2 of 3 with right hemisphere (atypical) speech dominance (P = 0.13). NIRS revealed increases in lateral inferior frontal total hemoglobin concentrations congruent with language dominance predicted by handedness/footedness in 18 of 24 subjects, including 100% of healthy right-handed subjects (P = 0.02).

CONCLUSION:

NIRS is a simple, non-invasive, safe modality for measuring cerebral blood flow. Further research and development of testing procedures and instrumentation are needed before routine implementation in pre-surgical testing.

PMID:
15276143
DOI:
10.1016/j.seizure.2003.09.008
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center