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Am J Cardiol. 2004 Aug 1;94(3):392-5.

Endothelial cell function in patients with Down's syndrome.

Author information

1
Division of Pediatric Cardiology, 2nd University of Medicine, Monaldi Hospital, Naples, Italy. mcappelli@tin.it

Abstract

Patients with Down's syndrome show an increased pulmonary vascular reactivity that could be due to an impaired vascular endothelial function, which is possibly related to increased oxidative stress. In 8 patients with Down's syndrome and 9 euploid patients of similar age, endothelium-dependent and -independent vasodilation was studied, measuring brachial flow velocity with an intravascular Doppler flow wire. Patients with Down's syndrome showed a significant impairment of endothelial function versus controls. In presence of the antioxidant vitamin C, endothelium-dependent vasodilation in the patients with Down's syndrome was only slightly, but not significantly, improved.

PMID:
15276117
DOI:
10.1016/j.amjcard.2004.04.047
[Indexed for MEDLINE]

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