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Parasitol Today. 1994 Feb;10(2):48-52.

What can GPI do for you?

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Department of Biochemistry, University of Dundee, Dundee, UK DD1 4HN.


Various functions for glycosylphosphatidylinositol (GPI) protein anchors have been described in mammalian and protozoan systems. These data suggest that some functions are common to higher and lower eukaryotes, whereas others may represent adaptations that are specifically advantageous to either unicellular or metazoan organisms. In this article, Mike Ferguson discusses the current theories of GPI function that have relevance to protozoan parasites and their mammalian hosts.


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