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Antimicrob Agents Chemother. 2004 Aug;48(8):3122-6.

Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing.

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  • 1Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California, USA.

Abstract

In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.

PMID:
15273130
PMCID:
PMC478552
DOI:
10.1128/AAC.48.8.3122-3126.2004
[PubMed - indexed for MEDLINE]
Free PMC Article
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