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Phys Med Biol. 2004 Jun 21;49(12):N155-63.

Diffuse optical tomography with physiological and spatial a priori constraints.

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1
Department of Biophysics and Biochemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. xintes@art.ca

Abstract

Diffuse optical tomography is a typical inverse problem plagued by ill-condition. To overcome this drawback, regularization or constraining techniques are incorporated in the inverse formulation. In this work, we investigate the enhancement in recovering functional parameters by using physiological and spatial a priori constraints. More accurate recovery of the two main functional parameters that are the blood volume and the relative saturation is demonstrated through simulations by using our method compared to actual techniques.

PMID:
15272687
[Indexed for MEDLINE]
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